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馮濤/于震維等（天壇醫院）Brain --Plasma tau-species positive neuron derived extracellular vesicles in progressive
supranuclear palsy
王伊龍等（天壇醫院）Cell --Nanoparticles hijack calvarial immune cells for CNS
drug delivery and stroke therapy
王擁軍等（天壇醫院）The Lancet --Tenecteplase versus standard medical treatment for basilar
artery occlusion within 24 h (TRACE-5): a multicentre,
prospective, randomised, open-label, blinded-endpoint,
superiority, phase 3 trial
郝峻巍等（宣武醫院）JAMA --Tenecteplase for Acute Non–Large Vessel Occlusion
4.5 to 24 Hours After Ischemic Stroke
The OPTION Randomized Clinical Trial
王伊龍等（天壇醫院）The Lancet --Efficacy and safety of minocycline in patients with acute
ischaemic stroke (EMPHASIS): a multicentre, double-blind,
randomised controlled trial
王擁軍等（天壇醫院）BMJ --Edaravone dexborneol versus placebo on functional outcomes in
patients with acute ischaemic stroke undergoing endovascular
thrombectomy (TASTE-2): randomised controlled trial
李子孝等（天壇醫院）BMJ --Effect of a clinical decision support system on stroke care quality
and outcomes in patients with acute ischaemic stroke (GOLDEN
BRIDGE II): cluster randomised clinical trial
牛曉輝等（積水潭醫院）The Lancet --Pimicotinib versus placebo for tenosynovial giant cell
tumour (MANEUVER): an international, randomised,
placebo-controlled, phase 3 trial
洪韜/張鴻祺等（宣武醫院）Brain --Angiogenic switching in cerebral cavernous
malformations driven by MAP3K3–PIK3CA synergy
侯勝平等（同仁醫院）npj Digital Medicine --Apolipoprotein E drives microglia activation in the
development of autoimmune uveitis through
up-regulation of peptidyl prolyl isomerase F
王擁軍等（天壇醫院）npj Digital Medicine --Deep learning-based brain age predicts stroke recurrence in acute ischemic
cerebrovascular disease
王碩等（天壇醫院）JAMA NEUROLOGY --Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture
郭力嘉/劉怡等（口腔醫院）Bioactive Materials --Mechanism and regulatory strategy study on promoting vascularized bone
regeneration via intracellular zinc ion transport
李玉琳等（安貞醫院）Immunity --Optogenetic vagal nerve stimulation attenuates heart
failure by limiting the generation f monocyte-derived
inflammatory CCRL2+ macrophages
邢卉春/王璽等（地壇醫院）Gut Microbes --Gut microbial metabolite butyrate suppresses
hepatocellular carcinoma growth via CXCL11-
dependent enhancement of natural killer cell
infiltration
盧潔/唐毅等（宣武醫院）Radiology --Modulation of Cortical and Hippocampal Functional MRI
Connectivity Following Transcranial Alternating Current
Stimulation in Mild Alzheimer Disease
金子兵等（同仁醫院）Science Bulletin --Juvenile macular degeneration in nonhuman primates generated by
germline knockout of ABCA4 gene
王剛/閆芳等（安定醫院）npj Digital Medicine --Randomized clinical trial of a digital
medication system to enhance adherence
in patients with severe mental disorders
孫英/王煒等（基礎醫學院）Advanced Science --Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During
Pulmonary Hypertension
梁慶豐等（同仁醫院）eBioMedicine --Bifunctional chemokine-nanobody fusion protein enhances neutrophil recruitment to impede Acanthamoeba immune
evasion
王剛/杜靜等（安定醫院）npj Science of Food --Long-term GABA supplementation
mitigates anxiety by modulating
complement and neuroinflammatory
pathways
唐毅等（宣武醫院）Science Bulletin --Coupled sleep rhythm disruption predicts cognitive decline in
Alzheimer's disease
劉磊等（基礎醫學院）Nature Communications --A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
王松靈等（基礎醫學院）PNAS --An atlas of early human mandibular endochondral
and osteogenic paracrine signaling regions of Meckel’s cartilage
王松靈等（基礎醫學院）Cell Reports --Integrated multi-omics profiling characterizes the crucial role of human dental epithelium during tooth development
閆致強等（基礎醫學院）Neuron --TMEM63B functions as a mammalian hyperosmolar
sensor for thirst
王松靈等（基礎醫學院）Science Bulletin --Nitrate ameliorates myelin loss and cognitive impairment in Alzheimer’s
disease through upregulation of neuronal sialin and subsequent
inhibition of TPPP phosphorylation
張晨/王偉/劉希成等（基礎醫學院）Cell Metabolism --Microbiota-derived lysophosphatidylcholine
alleviates Alzheimer’s disease pathology via
suppressing ferroptosis
盧潔/武力勇等（宣武醫院）Neurology --Association of Glymphatic Function With Clinical
Characteristics in Patients With Clinical and Asymptomatic Creutzfeldt-Jakob Disease
劉靜等（安貞醫院）Nature Communications --Effectiveness of treat-to-target cholesterollowering
interventions on cardiovascular
disease and all-cause mortality risk in the
community-dwelling population: a target
trial emulation
王偉等（基礎醫學院）Gut Microbes --B. vulgatus ameliorates high-fat diet-induced obesity through modulating
intestinal serotonin synthesis and lipid absorption in mice
趙繼宗/王碩等（天壇醫院）LANCET NEUROLOGY --Safety and efficacy of early versus delayed acetylsalicylic acid
after surgery for spontaneous intracerebral haemorrhage
in China (E-start): a prospective, multicentre, open-label,
blinded-endpoint, randomised trial
李子孝等（天壇醫院）INNOVATION --Beyond low-density lipoprotein cholesterol levels: Impact of prior statin treatment on ischemic stroke outcomes
張宏偉等（三博腦科醫院）Nature Communications --Non-secreting IL12 expressing oncolytic
adenovirus Ad-TD-nsIL12 in recurrent highgrade glioma: a phase I trial
吳若嘉等（藥學院）Nature Communications --Longitudinal ultra-sensitive mutation
burden sequencing for precise minimal residual disease assessment in AML
馬長生等（安貞醫院）JAMA --Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF The PROMPT-AF Randomized Clinical Trial
王雅杰等（地壇醫院）Journal of Infection --Synergistic evolution: The dynamic adaptation of SARS-CoV-2 and
human protective immunity in the real world
洪韜/張鴻祺等（宣武醫院）The American Journal of Human Genetics --GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas
逄宇等（胸科醫院）Cell Mol Immunol --Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
劉亞歐等（天壇醫院）Brain --Distinct virtual histology of grey matter atrophy in four neuroinflammatory diseases
武力勇等（宣武醫院）JAMA Neurology --Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases
王剛/周佳等（安定醫院）Brain Stimulation --Effect of add-on transcranial alternating current stimulation (tACS) in major depressive disorder: A randomized controlled trial
王剛/楊健等（安定醫院）Advanced Science --Integrated Single-Cell RNA-seq and ATAC-seq Reveals
Heterogeneous Differentiation of CD4+ Naive T Cell
Subsets is Associated with Response to Antidepressant
Treatment in Major Depressive Disorder
馮濤等（天壇醫院）Neurology --Distinctive Pattern of Metal Deposition in Neurologic
Wilson Disease
陰赪宏等（婦產醫院）Environmental Science & Technology --Associations of Ambient Particulate Matter with Maternal Thyroid
Autoimmunity and Thyroid Function in Early Pregnancy
吳燕等（基礎醫學院）PNAS --Bispecific antibodies targeting two glycoproteins on SFTSV
exhibit synergistic neutralization and protection in a
mouse model
馬偉等（基礎醫學院）Redox Biology --Iron accumulation in ovarian microenvironment damages the local redox
balance and oocyte quality in aging mice
馮濤等（天壇醫院）Science Advances --Molecular beacon–based detection of circulating
microRNA-containing extracellular vesicle as an α-synucleinopathy biomarker
王伊龍/王擁軍等（天壇醫院）JAMA Neurology --Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia The INSPIRES Randomized Clinical Trial
張建國等（天壇醫院）JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY --Contribution of basal ganglia activity to REM sleep disorder in Parkinson’s?disease
李纖/楊菲等（基礎醫學院）Cell Death & Differentiation --Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
王伽伯等（中醫藥學院）Journal of Advanced Research --Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2
洪韜等（宣武醫院）Angiogenesis --Somatic Braf V600E mutation in the cerebral endothelium induces brain arteriovenous malformations
李玉琳等（安貞醫院）ACS Nano --One Endothelium-Targeted Combined Nucleic Acid Delivery System for Myocardial Infarction Therapy
馮芝恩/韓正學等（口腔醫院）Journal of Extracellular Vesicles --The small extracellular vesicle-mediated intercellular
transformation of CXCR1Low to CXCR1High tumour cells promotes the progression of head and neck squamous cell carcinoma
馬偉等（基礎醫學院）Autophagy --PLD1 promotes spindle assembly and migration
through regulating autophagy in mouse oocyte meiosis
李長龍等（基礎醫學院）Gastric Cancer --Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6
陰赪宏等（婦產醫院）Phytomedicine --Baicalein improves the symptoms of polycystic ovary syndrome by
mitigating oxidative stress and ferroptosis in the ovary and gravid placenta
柳柯等（友誼醫院）ACS Nano --Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally
Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor?Poly(DL-lactic acid-coglycolic
acid)-Loaded Hydrogel
賈建平等（宣武醫院）NEJM --Biomarker Changes during 20 Years
Preceding Alzheimer’s Disease
郭秀海等（宣武醫院）BMC MED --Effects of acetazolamide combined with remote ischemic preconditioning on risk
of acute mountain sickness: a randomized
clinical trial
饒毅等（首都醫科大學）Sci Adv --Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis
賈旺等（天壇醫院）NPJ Digit Med --Wireless facial biosensing system for monitoring facial palsy
with flexible microneedle electrode arrays
江濤等（天壇醫院）Sig Transduct Target Ther --Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape
金子兵等（同仁醫院）Elife --RNA fusion in human retinal development
李巍等（兒童醫院）ATVB --Physical Contacts Between Mitochondria and WPBs Participate in WPB Maturation
石漢平等（世紀壇醫院）JAMA Netw Open --New-Onset Age of Nonalcoholic Fatty Liver Disease and Cancer Risk
安靜等（基礎醫學院）J Virol --Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice
王擁軍等（天壇醫院）BMJ --Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial

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